Vivian Hook Selected Research

Enzymes

7/2022	Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions.
1/2022	Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders.
1/2021	Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.

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Vivian Hook Research Topics

Disease

18	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 09/2005
8	Memory Disorders (Memory Loss) 01/2023 - 08/2010
5	Inflammation (Inflammations) 07/2022 - 01/2015
5	Brain Diseases (Brain Disorder) 07/2022 - 10/2014
5	Pain (Aches) 01/2022 - 12/2010
5	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022 - 03/2014
3	Schizophrenia (Dementia Praecox) 02/2024 - 10/2014
3	Amyloid Plaque 01/2023 - 08/2008
3	Huntington Disease (Huntington's Disease) 01/2023 - 01/2015
3	COVID-19 01/2022 - 12/2020
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 01/2020
2	Tauopathies 01/2023 - 01/2021
2	Hypertension (High Blood Pressure) 01/2023 - 12/2010
2	Frontotemporal Dementia (Semantic Dementia) 01/2023 - 01/2021
2	Edema (Dropsy) 01/2023 - 01/2015
2	Cognitive Dysfunction 01/2023 - 01/2022
2	Epilepsy (Aura) 01/2022 - 01/2015
2	Multiple Sclerosis 01/2022 - 01/2015
2	Hyperalgesia 01/2016 - 04/2013
2	Wounds and Injuries (Trauma) 01/2015 - 03/2014
2	Neuroblastoma 08/2013 - 05/2012
1	Dementia (Dementias) 01/2023
1	Periodontitis 01/2022
1	Ischemia 01/2022
1	Nervous System Diseases (Neurological Disorders) 01/2022
1	Pick Disease of the Brain (Pick's Disease) 01/2021
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2021
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2021
1	Corticobasal Degeneration 01/2021
1	Brain Injuries (Brain Injury) 01/2020
1	Parasitic Diseases (Parasitic Disease) 10/2019
1	Schistosomiasis (Bilharziasis) 10/2019
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2019
1	Chronic Pain 01/2016
1	Brain Ischemia (Cerebral Ischemia) 01/2015
1	Rheumatoid Arthritis 01/2015
1	Hemorrhage 01/2015
1	Intracranial Aneurysm (Cerebral Aneurysm) 01/2015
1	Infections 01/2015
1	Lymphoma (Lymphomas) 10/2011
1	Obesity 12/2010
1	Neoplasms (Cancer) 12/2010
1	Mental Disorders (Mental Disorder) 12/2010
1	Pathologic Processes 10/2010
1	Pheochromocytoma 10/2010
1	Mitochondrial Diseases (Mitochondrial Disease) 06/2010

Drug/Important Bio-Agent (IBA)

15	Cathepsin BIBA 01/2023 - 09/2005
11	Peptides (Polypeptides)IBA 01/2022 - 02/2007
8	NeuropeptidesIBA 02/2024 - 10/2010
7	Amyloid (Amyloid Fibrils)IBA 01/2023 - 08/2008
7	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2012
7	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2023 - 09/2005
6	Cysteine Proteases (Cysteine Protease)IBA 01/2023 - 01/2011
6	Proteins (Proteins, Gene)FDA Link 06/2021 - 08/2008
6	Amyloid beta-PeptidesIBA 08/2013 - 09/2005
5	Cysteine Proteinase InhibitorsIBA 01/2021 - 02/2007
5	Neurotransmitter Agents (Neurotransmitter)IBA 01/2016 - 01/2012
4	Cathepsin LIBA 01/2022 - 10/2011
4	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 01/2012
3	Protein Isoforms (Isoforms)IBA 01/2023 - 01/2021
3	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA 01/2023 - 01/2014
3	EnzymesIBA 07/2022 - 01/2021
3	CathepsinsIBA 08/2018 - 01/2012
2	ProteomeIBA 01/2023 - 01/2022
2	gallinamide AIBA 01/2022 - 12/2020
2	Dynorphins (Dynorphin)IBA 01/2016 - 04/2013
2	CatecholaminesIBA 10/2014 - 01/2012
1	NeurotensinIBA 02/2024
1	Natriuretic PeptidesIBA 02/2024
1	Chromogranin BIBA 02/2024
1	Complementary DNA (cDNA)IBA 01/2023
1	DiureticsIBA 01/2023
1	Bumetanide (Bumex)FDA LinkGeneric 01/2023
1	Apolipoprotein E4IBA 01/2023
1	PresenilinsIBA 01/2023
1	cathepsin SIBA 01/2022
1	polyglutamineIBA 01/2022
1	Biological FactorsIBA 01/2022
1	Opiate AlkaloidsIBA 01/2022
1	Huntingtin ProteinIBA 01/2022
1	Caveolin 1IBA 06/2021
1	Membrane LipidsIBA 06/2021
1	tau Proteins (tau Protein)IBA 01/2021
1	Antiviral Agents (Antivirals)IBA 12/2020
1	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2019
1	LithiumIBA 01/2019
1	Nicotine FDA Link 01/2019
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2019
1	Epinephrine (Adrenaline)FDA LinkGeneric 01/2019
1	Dopamine (Intropin)FDA LinkGeneric 01/2019
1	AntibodiesIBA 01/2016
1	Opioid Analgesics (Opioids)IBA 01/2016
1	GalaninIBA 08/2013
1	Immune Sera (Antisera)IBA 04/2013
1	EnkephalinsIBA 05/2012
1	Cysteine (L-Cysteine)FDA Link 01/2012
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 10/2011
1	Amino Acids FDA Link 12/2010

Therapy/Procedure

4	Therapeutics 01/2023 - 03/2014
1	Craniotomy 01/2020